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‘Human beings have a lot of ribonuclease enzyme that breaks down RNA, so most people assumed I just had made a trivial observation on sloppy experimental work,’ Lindahl explains.

‘But then I did the experiment over a number of times, I made the RNA myself, so I was sure it wasn’t contaminated, and then I found the RNA slowly, slowly decomposed, always at the same rate.’ This observation was important, according to Lindahl, because it demonstrated there was a regular decay process occurring and wasn’t simply an artefact of contamination.

The passing of time has been kind to Franklyn, who like her friend Marie Curie, operated in an era when science was a fraternity and women were not welcome. Several generations later, Franklyn’s story has inspired books, movies, plays, documentaries, and various other epitaphs.

The majority of them acknowledge her role as the unofficial ‘godmother’ of DNA.

The one thing we know for sure about Rosalind Franklyn is that innovation was in her DNA. Rarely can the significance of a single photo have been more significant than that taken by Dr Franklyn back in 1951 at Kings College, London, using a process known as x-ray diffraction.

‘So, the thymines tend to decay to form uracil – that’s an abnormal base in DNA.’Such base anomalies are unable to hydrogen-bond with their previous base partner and resort to forming new bonds with adjacent bases.Rosalind Franklyn may no longer be alive and her name never appeared on a Nobel Prize. Francis Crick was an English molecular biologist who shared, with James Watson, the 1962 Nobel Prize in Physiology or Medicine for elucidating the double-helix structure of DNA. For the latter part of his career, he was at the Salk Institute, California.To salvage them, we use the tools at our disposal to repair them, iron out flaws and keep them whole.The 2015 chemistry Nobel laureates realised that the very molecular structure that makes us who we are, DNA, is locked in the same perpetual struggle.




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